Nonstop destruction

Nonsense mRNA suppression via nonstop decay

Nonsense-mediated mRNA decay is the process by which mRNAs bearing premature stop codons are recognized and cleared from the cell. While considerable information has accumulated regarding recognition of the premature stop codon, less is known about the ensuing mRNA suppression. During the characterization of a second, distinct translational surveillance pathway (nonstop mRNA decay), we trapped ...

Release of Nonstop Ribosomes Is Essential

UNLABELLED Bacterial ribosomes frequently translate to the 3' end of an mRNA without terminating at a stop codon. Almost all bacteria use the transfer-messenger RNA (tmRNA)-based trans-translation pathway to release these "nonstop" ribosomes and maintain protein synthesis capacity. trans-translation is essential in some species, but in others, such as Caulobacter crescentus, trans-translation c...

Nonstop Flying Is Safer than Driving

Query processing using HP NonStop SQL/MP software

Query optimization.............................................................................................................................. 3 Generating the plan ......................................................................................................................... 3 Serial execution plans ......................................................................................

Evaluation of Lump-sum Update Methods for Nonstop Service System

In many mission-critical systems, the lump-sum update of large amounts of data is performed. On the one hand, with the development of internet business, nonstop online services have become to be provided in many missioncritical systems. So, the lump-sum update has to be performed concurrently with the online entry. However, in the actual mission-critical systems, there are various kinds of lump...